Genetic Engineering Publications - GEG Tech top picks

The authors used the CRISPR/Cas9 system to generate biallelic SOD2 disruption in HEK293T cells. The phenotype of these cells is primarily characterized by impaired mitochondrial bioenergetics. The activities of mitochondrial complex I and II were both significantly impaired by the absence of MnSOD activity, By creating this model they provide a novel tool with which to study the consequences of lack of MnSOD activity in human cells.

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