The field of genetic engineering – we call it Gengineering- has been revolutionizing a growing list of scientific and engineering areas starting with fundamental biomolecular research and quickly reaching bioproduction, agro-food and health care industries, just to name the first sectors impacted. Over the last years, a new generation of gengineering technologies has emerged and undoubtedly show up game-changing. The development of new gene editing tools such as meganucleases, zinc finger nucleases (ZFNs), transcription activator-like effector nucleases (TALENs), and the CRISPR/Cas9 system, allow a much more precise, efficient, flexible editing of the genome, as well as lower costs compared to previous strategies (see illustration). Most recently, several proof of concept have been established about the epigenome editing or the RNA editing.....
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