Genetic Engineering Publications - GEG Tech top picks

Here, the authors review the applications of programmable nucleases in biology and medicine with a focus on CRISPR system. They discuss about the impact of the unprecedented ability to modify cells offer by CRISPR to the scientists and about the consequence of the off targets.

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The authors generated a BCAM-AKT2 fusion via chromosomal translocation using the CRISPR/Cas9 system leads to focus formation in both OVCAR8 and HEK-293T cell lines, suggesting that BCAM-AKT2 is oncogenic. Their results indicate that BCAM-AKT2 expression is a new mechanism of AKT2 kinase activation in HGSC. BCAM-AKT2 is the only fusion gene in HGSC that is proven to translate an aberrant yet functional kinase fusion protein with oncogenic properties.

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