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Genetic Engineering Publications - GEG Tech top picks
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BigField GEG Tech's insight:
The authors demonstrated that high-aspect-ratio, mesoporous silica rods (MSRs) injected with a needle spontaneously assemble in vivo to form macroporous structures that provide a 3D cellular microenvironment for host immune cells. In mice, substantial numbers of dendritic cells are recruited to the pores between the scaffold rods. These findings suggest that injectable MSRs may serve as a multifunctional vaccine platform to modulate host immune cell function and provoke adaptive immune responses. 
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The authors discuss the practical advantages of the CRISPR-Cas9 system over conventional and other nuclease-based targeting technologies and provide suggestions for the use of this technology to address immunological questions.
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In this Opinion article, scientists present a general scenario for the origin of adaptive immunity from mobile elements and innate immune systems.
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Researchers explored the impact of dietary-derived trans-vaccenic acid (TVA) on effector cytotoxic T lymphocyte functions and anti-tumor immunity in in vivo settings using CRISPR. Overall, the results of the study showed that dietary trans-vaccenic acid enhances effector cytotoxic T lymphocyte activity and anti-tumor immunity in in vivo contexts. In contrast to intra-organism SCFA derived from intestinal microbes functioning as agonists of the G protein-coupled immunoregulatory receptor 43 (GPR43), extra-organism VAT reprogrammed CD8+ T lymphocytes by extrinsic regulation to inactivate GPR43. The results of the study contribute to a better understanding of the molecular links between nutrition and human pathophysiology, with implications for future research into the function of circulating nutrients in health and disease. Further research is needed to improve understanding of the effector pathways downstream of GPR43 and elucidate the underlying processes.