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Genetic Engineering Publications - GEG Tech top picks
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This review presents the mechanisms of different gene editing strategies and describes each of the common nuclease-based platforms, including zinc finger nucleases, TALE nucleases, meganucleases, and the CRISPR/Cas9 system. The authors summarize the progress made in applying genome editing to various areas of gene and cell therapy, including antiviral strategies, immunotherapies, and the treatment of monogenic hereditary disorders. 
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In this study, the authors identified dasatinib as a drug that can temporarily inactivate CAR T cells to help reduce acute toxicity, allowing the T cells to recover their antitumor effects after the drug is withdrawn.