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MicroRNAs are small and non-coding RNA molecules with the master role in regulation of gene expression at post-transcriptional/translational levels.
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In this study, the scientists clone CRISPR/cas9 constructs with single-guide RNAs specifically targeting biogenesis processing sites of selected microRNAs; and they find that CRISPR/cas9 can robustly and specifically reduce the expression of these microRNAs up to 96%. This is the first demonstration of the long term stability of microRNA knockdown phenotype by CRISPR/cas9 in both in vitro and in vivo models.