This work describes a new high-throughput screening platform for the optimization of CRISPR-Cas9 delivery strategies. The results suggest design principles for the development of materials and transfection strategies with lipid-based materials. The presented platform could be applied to rapidly optimize materials for gene-editing in a variety of cell/tissue types in order to advance genomic medicine, regenerative biology and drug discovery.
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This work describes a new high-throughput screening platform for the optimization of CRISPR-Cas9 delivery strategies. The results suggest design principles for the development of materials and transfection strategies with lipid-based materials. The presented platform could be applied to rapidly optimize materials for gene-editing in a variety of cell/tissue types in order to advance genomic medicine, regenerative biology and drug discovery.