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RNA-guided epigenome editing with Cas9 fused to an acetyltransferase domain activates gene expression through modification of promoters and enhancers.
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The authors describe a programmable, CRISPR-Cas9-based acetyltransferase consisting of the nuclease-null dCas9 protein fused to the catalytic core of the human acetyltransferase p300. The fusion protein catalyzes acetylation of histone H3 lysine 27 at its target sites, leading to robust transcriptional activation of target genes from promoters and both proximal and distal enhancers.
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