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Genetic Engineering Publications - GEG Tech top picks
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The "new genetics" promises to change faulty genes of future generations by introducing new, functioning genes using "designer sperm." Research shows that introducing genetic material via a viral vector into mouse sperm leads to the presence and...
BigField GEG Tech's insight:
The lentiviral transduction of spermatozoa, an original and efficient strategy to generate transgenic models!
BigField GEG Tech's curator insight,
December 5, 2013 9:04 AM
The lentiviral transduction of spermatozoa, an original and efficient strategy to generate transgenic models!
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Scoop.it!
BigField GEG Tech's insight:
In this study, the authors show transfection-based multiplexed delivery of CRISPR/Cas9 to the pancreas of adult mice, allowing simultaneous editing of multiple gene sets in individual cells. They use the method to induce pancreatic cancer and exploit CRISPR/Cas9 mutational signatures for phylogenetic tracking of metastatic disease. They find that low-frequency mosaic pattern of transfection-based CRISPR/Cas9 delivery faithfully recapitulates the stochastic nature of human tumorigenesis, supporting wide applicability for biological/preclinical research.
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Researchers from Inserm and Université de Rennes recently identified a new bacterial toxin which they transformed into potent antibiotics active against various bacteria responsible for human infections.
Novel antibiotics effective against gram-positive and -negative multi-resistant bacteria with limited resistance