Genetic Engineering Publications - GEG Tech top picks

As a proof of concept, the scientists took advantage of NZB/BALB heteroplasmic mice, which contain two mtDNA haplotypes, BALB and NZB, and selectively prevented their germline transmission using either mitochondria-targeted restriction endonucleases or TALENs. In addition, they successfully reduced human mutated mtDNA levels responsible for Leber’s hereditary optic neuropathy and neurogenic muscle weakness, ataxia, and retinitis pigmentosa , in mammalian oocytes using mitochondria-targeted TALEN.

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