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Scoop.it!
Cellular reprogramming by transient expression of Yamanaka factors ameliorates age-associated 
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Scoop.it!
BigField GEG Tech's insight:
In this study, the authors use CRISPR-Cas9–based method for gene editing directly in the mouse adult pancreas, They show that de-repression of p57 upon combined bromodomain extraterminal and histone deacetylase inhibition is required for the induction of combination therapy–induced cell death in pancreatic ductal adenocarcinoma.
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Here, the scientists report that partial reprogramming by short-term cyclic expression of Oct4, Sox2, Klf4, and c-Myc (OSKM) ameliorates cellular and physiological hallmarks of aging and prolongs lifespan in a mouse model of premature aging.