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Cell Transplant. 2017 Mar 3. doi: 10.3727/096368916X695137. [Epub ahead of print] 
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Brain tumor modeling using the CRISPR/Cas9 system: state of the art and view to the future
BigField GEG Tech's insight:
In this review, the authors proposed that brain tumor modeling could be well established via CRISPR/Cas9 techniques. CRISPR/Cas9-mediated brain tumor modeling was likely to be more suitable for figuring out the pathogenesis of brain tumors, as CRISPR/Cas9 platform was a simple and more efficient biological toolbox for implementing mutagenesis of oncogenes or tumor suppressors that were closely linked with brain tumors.
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Anion channelrhodopsins are light-sensitive chloride channels that can be used as optogenetic inhibitors. Mohammad et al. report their application in Drosophila, showing that various behaviors can be inhibited in a light-dependent manner.
BigField GEG Tech's insight:
Here the scientists show that anion channelrhodopsins can be used to specifically and rapidly inhibit neural systems involved in Drosophila locomotion, wing expansion, memory retrieval and gustation, thus demonstrating their broad utility in the circuit analysis of behavior.
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This review introduces the clinical manifestations of three distinct neurodegenerative diseases and the applications of the gene-editing technology on these debilitating diseases.