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Genetic Engineering Publications - GEG Tech top picks
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Recent advancement in genome engineering technology is changing the landscape of biological research and providing neuroscientists with an opportunity to develop new methodologies to ask critical research questions. This advancement is highlighted by the increased use of programmable DNA-binding agents (PDBAs) such as transcription activator-like effector (TALE) and RNA-guided clustered regularly interspaced short palindromic repeats (CRISPR)/CRISPR associated (Cas) systems. These PDBAs fused or co-expressed with various effector domains allow precise modification of genomic sequences and gene expression levels. These technologies mirror and extend beyond classic gene targeting methods contributing to the development of novel tools for basic and clinical neuroscience. In this Review, we discuss the recent development in genome engineering and potential applications of this technology in the field of neuroscience.
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In this Review, the authors discuss the recent development in genome engineering and potential applications of this technology in the field of neuroscience. 
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In the last decade, new technologies such as optogenetics, chemogenetics and the CRISPR-Cas system have begun to transform how biologists understand the finer details associated with sleep-wake regulation. Here, the authors detail how some of the newest technologies are being applied to understand the neural circuits underlying sleep and wake.