Human pluripotent stem cells are differentiated into inner ear organoids containing cells similar to hair cells and sensory neurons.
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Genetic Engineering Publications - GEG Tech top picks
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A new study has described the use of gene editing to model genetic kidney disease in 3D kidney organoids generated from hPSCs. “Our most exciting finding was that the CRISPR-mutant organoids can recapitulate features of genetic kidney disease,” says researcher Benjamin Freedman. “These findings teach us that principal features of kidney architecture and disease are cell-intrinsic.” 
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The growth and structural formation of the human cortex can be modeled in vitro using
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Here the authors report a method for differentiating human pluripotent stem cells to inner ear organoids that harbor functional hair cells. Using a three-dimensional culture system, the authors modulate TGF, BMP, FGF, and WNT signaling to generate multiple otic-vesicle-like structures from a single stem-cell aggregate. Over 2 months, the vesicles develop into inner ear organoids with sensory epithelia that are innervated by sensory neurons. Their culture system should facilitate the study of human inner ear development and research on therapies for diseases of the inner ear.