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The genome editing activity of CRISPR-Cas9 can be switched on and off by light using split Cas9 fragments fused tophotoinducible dimerization domains.
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Here, the authors describe an engineered photoactivatable Cas9 (paCas9). In response to blue light irradiation, paCas9 expressed in human embryonic kidney 293T cells induces targeted genome sequence modifications through both nonhomologous end joining and homology-directed repair pathways.
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