Genetic Engineering Publications - GEG Tech top picks

In this study the scientists show that the commonly used Cas9 can be modified to recognize alternative protospacer adjacent motif (PAM) sequences using structural information, bacterial selection-based directed evolution, and combinatorial design. These altered PAM specificity variants enable robust editing of endogenous gene sites in zebrafish and human cells and they identify and characterize a SpCas9 variant that exhibits improved specificity in human cells.

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