Researchers helped develop a specially engineered retinal patch to treat people with sudden, severe sight loss.
The results of this groundbreaking clinical study, published in Nature Biotechnology, describe the effective implantation of a specially engineered patch of retinal pigment epithelium cells derived from stem cells to treat people with sudden severe sight loss from wet AMD -- the form that afflicted Waters. This is the first description of a completely engineered tissue that has been successfully used in this way.
The scientists generated conditional knockout mice deficient in various Slit and Robo proteins and found that Slit2 potently and selectively promoted angiogenesis via Robo1 and Robo2 in mouse postnatal retina and in a model of ocular neovascular disease.Thus, Slit2 blockade could potentially be used therapeutically to inhibit angiogenesis in individuals with ocular neovascular disease.
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