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Genetic Engineering Publications - GEG Tech top picks
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BigField GEG Tech's insight:
The authors develop a cross-chiral RNA polymerase, using in vitro evolution starting from a population of random-sequence RNAs. The enzyme’s activity is sufficient to generate full-length copies of its enantiomer through the templated joining of 11 component oligonucleotides. 
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BigField GEG Tech's insight:
In this study, the scientists create post-transcriptional circuits using RNA-binding proteins, which can be wired in a plug-and-play fashion to create networks of higher complexity. They show that the circuits function in mammalian cells when encoded in modified mRNA or self-replicating RNA.
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In this study, the authors report that multiple gRNAs linked with self-cleaving ribozymes and/or tRNA could be simultaneously expressed from a single U6 promoter to exert genome editing of dystrophin and myosin binding protein C3 in human and mouse cells.