Genetic Engineering Publications - GEG Tech top picks

Researchers explored the impact of dietary-derived trans-vaccenic acid (TVA) on effector cytotoxic T lymphocyte functions and anti-tumor immunity in in vivo settings using CRISPR. Overall, the results of the study showed that dietary trans-vaccenic acid enhances effector cytotoxic T lymphocyte activity and anti-tumor immunity in in vivo contexts. In contrast to intra-organism SCFA derived from intestinal microbes functioning as agonists of the G protein-coupled immunoregulatory receptor 43 (GPR43), extra-organism VAT reprogrammed CD8+ T lymphocytes by extrinsic regulation to inactivate GPR43. The results of the study contribute to a better understanding of the molecular links between nutrition and human pathophysiology, with implications for future research into the function of circulating nutrients in health and disease. Further research is needed to improve understanding of the effector pathways downstream of GPR43 and elucidate the underlying processes.