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Genetic Engineering Publications - GEG Tech top picks
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Scoop.it!
BigField GEG Tech's insight:
This review gives a short primer on gene editing followed by some of the foundational work in gene editing and subsequently a discussion of programmable nucleases leading to a description of Zinc Finger Nuclease, TALENs and CRISPRs. 
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Scoop.it!
BigField GEG Tech's insight:
In this review, the authors compare methods for detecting nuclease off-target mutations. They also review methods for profiling genome-wide off-target effects and discuss how to reduce or avoid offtarget mutations.
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The past decade has brought rapid and significant innovations in genome-editing techniques. For the first time researchers have the opportunity to manipulate essentially any gene in a plethora of cells and organisms, using targeted nucleases that were designed for sequence-specific binding of the DNA.