Here the authors demonstrate that the class 2 type VI RNA-guided RNA-targeting CRISPR–Cas effector Cas13a (previously known as C2c2) can be engineered for mammalian cell RNA knockdown and binding. Their results establish CRISPR–Cas13a as a flexible platform for studying RNA in mammalian cells and therapeutic development.
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Here the authors demonstrate that the class 2 type VI RNA-guided RNA-targeting CRISPR–Cas effector Cas13a (previously known as C2c2) can be engineered for mammalian cell RNA knockdown and binding. Their results establish CRISPR–Cas13a as a flexible platform for studying RNA in mammalian cells and therapeutic development.