Genetic Engineering Publications - GEG Tech top picks

The sigma-2 receptor (S2R) is a potential therapeutic target for cancer and neuronal diseases. However, the identity of the S2R has remained a matter of debate. Recently, the progesterone receptor membrane component 1 (PGRMC1), a 25 kDa protein, was reported to be the S2R. To confirm this identification, the scientists created PGRMC1 knockout NSC34 cell lines using the CRISPR/Cas9 technology. Their results clarify that PGRMC1 and the S2R are distinct binding sites expressed by different genes.