In this study, the authors use CRISPR-Cas9–based method for gene editing directly in the mouse adult pancreas, They show that de-repression of p57 upon combined bromodomain extraterminal and histone deacetylase inhibition is required for the induction of combination therapy–induced cell death in pancreatic ductal adenocarcinoma.
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In this study, the authors use CRISPR-Cas9–based method for gene editing directly in the mouse adult pancreas, They show that de-repression of p57 upon combined bromodomain extraterminal and histone deacetylase inhibition is required for the induction of combination therapy–induced cell death in pancreatic ductal adenocarcinoma.
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