Genetic Engineering Publications - GEG Tech top picks

In this work, the scientists used CRISPR/Cas9 editing to modify CHO cells to enforce high mTORC1 activity by knocking-out TSC2, a major mTOR inhibitory protein, or PTEN, a phosphatase that attenuates the PI3K/AKT/mTOR pathway. These data underscore manipulation of TSC as a strategy to improve performance of CHO cell in bioreactors.