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DNA-binding phage-assisted continuous evolution improves the specificity of DNA-binding proteins, as demonstrated with TALENs.
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The scientists present in this work a DNA-binding phage-assisted continuous evolution (DB-PACE) as a general approach for the laboratory evolution of DNA-binding activity and specificity. They used this system to generate transcription activator–like effectors nucleases (TALENs) with broadly improved DNA cleavage specificity, establishing DB-PACE as a versatile approach for improving the accuracy of genome-editing agents.
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