In this study, the authors present DNA-binding phage-assisted continuous evolution (DB-PACE) to generate transcription activator–like effectors nucleases (TALENs) with broadly improved DNA cleavage specificity, establishing DB-PACE as a versatile approach for improving the accuracy of genome-editing agents.
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In this study, the authors present DNA-binding phage-assisted continuous evolution (DB-PACE) to generate transcription activator–like effectors nucleases (TALENs) with broadly improved DNA cleavage specificity, establishing DB-PACE as a versatile approach for improving the accuracy of genome-editing agents.
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