Here, the scientists report on the structures of Cas1-Cas2-dual-forked DNA complexes in an effort toward understanding how the protospacer is sampled prior to insertion into the CRISPR locus. Their study provides important structure-based mechanistic insights into PAM-dependent spacer acquisition.
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Here, the scientists report on the structures of Cas1-Cas2-dual-forked DNA complexes in an effort toward understanding how the protospacer is sampled prior to insertion into the CRISPR locus. Their study provides important structure-based mechanistic insights into PAM-dependent spacer acquisition.
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