In this study, the scientists used the CRISPR-Cas9 system to target exons encoding functional protein domains. A screen of 192 chromatin regulatory domains in murine acute myeloid leukemia cells identifies six known drug targets and 19 additional dependencies.
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In this study, the scientists used the CRISPR-Cas9 system to target exons encoding functional protein domains. A screen of 192 chromatin regulatory domains in murine acute myeloid leukemia cells identifies six known drug targets and 19 additional dependencies.
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