Regulatory elements for specific human genes are rapidly identified with CRISPR epigenome editing.
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Large genome-mapping consortia and thousands of genome-wide association studies have identified non-protein-coding elements in the genome as having a central role in various biological processes. However, decoding the functions of the millions of putative regulatory elements discovered in these studies remains challenging. Here the scientists describe CRISPR–Cas9-based epigenomic regulatory element screening (CERES) for improved high-throughput screening of regulatory element activity in the native genomic context. This technology allows the high-throughput functional annotation of putative regulatory elements in their native chromosomal context.