By reprogramming rod to cone-like photoreceptors in situ by inactivating Nrl or Nr2e3 using CRISPR system, the authors show an increase in cone-like cells with remarkable concomitant preservation of both cone and rod photoreceptors and retinal tissue, with restoration of visual function. Their approach demonstrates the feasibility of cellular reprogramming in preventing degeneration and preserving tissue and function, and points to a novel approach in treating human diseases in a gene and mutation independent manner.
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By reprogramming rod to cone-like photoreceptors in situ by inactivating Nrl or Nr2e3 using CRISPR system, the authors show an increase in cone-like cells with remarkable concomitant preservation of both cone and rod photoreceptors and retinal tissue, with restoration of visual function. Their approach demonstrates the feasibility of cellular reprogramming in preventing degeneration and preserving tissue and function, and points to a novel approach in treating human diseases in a gene and mutation independent manner.