A new study has described the use of gene editing to model genetic kidney disease in 3D kidney organoids generated from hPSCs. “Our most exciting finding was that the CRISPR-mutant organoids can recapitulate features of genetic kidney disease,” says researcher Benjamin Freedman. “These findings teach us that principal features of kidney architecture and disease are cell-intrinsic.”
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A new study has described the use of gene editing to model genetic kidney disease in 3D kidney organoids generated from hPSCs. “Our most exciting finding was that the CRISPR-mutant organoids can recapitulate features of genetic kidney disease,” says researcher Benjamin Freedman. “These findings teach us that principal features of kidney architecture and disease are cell-intrinsic.”
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