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Transcription activator-like effector nucleases (TALENs) are a new technology for modifying the genome at specific loci of interest. Hockemeyer et al. now demonstrate the utility of TALENs for gene targeting in human pluripotent stem cells. 
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"We leverage codon degeneracy and type IIs restriction enzymes to generate orthogonal ligation linkers between individual repeat monomers, thus allowing full-length, customized, repeat domains to be constructed by hierarchical ligation. We" ... "demonstrate that they can specifically modulate transcription of endogenous genes (SOX2 and KLF4) in human cells"
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One of two papers describing the original discovery of a linear code for DNA-binding site prediction
Image: Adam Bogdanove and Harry Horner/Iowa State University; false color: Yael Kats/Science
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A TAL effector is a protein of bacterial origin and is able to bind to DNA sequences. The bound sequence is defined by the structure of the TAL effector protein. Manipulate the effector protein and you can direct to any binding site you want. Powerful biotechnology, I say...
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A "Golden TAL Technology" to assemble custom DNA binding domains and their use es activators in human cells
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The other paper describing the TAL effector code including its powerful application to design artifical DNA binding domains
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From
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This article describes how the DNA binding specificity of TAL effectors was discovered
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